1 Loss of PDGF - B activity increases hepatic vascular 2 permeability and enhances insulin sensitivity 3 4 Running title : PDGF - B deficiency enhances insulin sensitivity
نویسندگان
چکیده
Running title: PDGF-B deficiency enhances insulin sensitivity 5 6 Summer M. Raines, Oliver C. Richards, Lindsay R. Schneider, Kathryn L. Schueler, Mary 7 E. Rabaglia, Angie T. Oler, Donald S. Stapleton, Guillem Genové, John A. Dawson, Christer 8 Betsholtz, and Alan D. Attie 9 10 11 Department of Biochemistry; University of Wisconsin-Madison; Madison, WI 53706 12 Graduate Program in Cellular and Molecular Biology; University of Wisconsin-Madison; 13 Madison, WI 53706 14 Graduate Program in Cellular and Molecular Pathology; University of Wisconsin-Madison; 15 Madison, WI 53706 16 Department of Medical Biochemistry and Biophysics; Karolinska Institute; Stockholm, Sweden 17 Department of Biostatistics and Medical Informatics; University of Wisconsin-Madison; 18 Madison, WI 53706 19 Corresponding author: 433 Babcock Drive, Madison, WI 53706; phone: 608-262-1372; fax: 20 608-263-9609; Email: [email protected] 21 22
منابع مشابه
Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.
Hepatic vasculature is not thought to pose a permeability barrier for diffusion of macromolecules from the bloodstream to hepatocytes. In contrast, in extrahepatic tissues, the microvasculature is critically important for insulin action, because transport of insulin across the endothelial cell layer is rate limiting for insulin-stimulated glucose disposal. However, very little is known concerni...
متن کاملChronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B.
Hyperinsulinemia plays a major role in the pathogenesis of vascular disease. Restenosis occurs at an accelerated rate in hyperinsulinemia and is dependent on increased vascular smooth muscle cell movement from media to neointima. PDGF plays a critical role in mediating neointima formation in models of vascular injury. We have reported that PDGF increases the levels of protein tyrosine phosphata...
متن کاملTrans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway
Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of tran...
متن کاملMagnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats
Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in elderly type 2 diabetes using a rat model and to provide experimental evidence for insulin resistance improvement by magn...
متن کاملConjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...
متن کامل